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RAS Proteins

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction).

The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer.

High occurrences of KRAS mutations in some types of cancers make KRAS one of the most important targets in oncology for drug development.  The five most frequent KRAS mutations are G12C, G12D, G12V, G13D, and Q61H. For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression.

Amid Biosciences offers recombinant biotinylated and non-biotinylated forms of KRAS proteins to advance drug discovery and medical research. Loading of the KRAS proteins with nucleotides or nucleotides' analogs can be performed if requested as a custom service.