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Rheb Protein Human Recombinant Biotinylated | Ras homolog enriched in brain | an important mediator between the tumor suppressor proteins TSC1 and TSC2 and the mammalian target of rapamycin to stimulate cell growth

Amid Biosciences | Protein Engineering Company

Rheb Protein, Human, Recombinant, Biotinylated

$ 800.00

Rheb (Ras homolog enriched in brain) is a small GTPase that functions as an important mediator between the tumor suppressor proteins TSC1. Rheb shares about 30–40% sequence identity with members of the Ras/Rap subfamily of small GTPases. Human Rheb consists of 184 amino acid residues. The 169 N-terminal residues form the GTPase domain; the 15 C-terminal residues are hypervariable with a flexible structure and comprise a conserved carboxyl CAAX motif that plays important roles in the farnesylation of Rheb and its association with membrane (1).

Recombinant Rheb protein with the N-terminal AviTag™ peptide and His-tag is produced in E. coli cells and site-specifically biotinylated at AviTag with BirA enzyme (

Tag(s): The N-terminal 8XHis and AviTag
Amino Acids: 1-184 of Rheb (UniProt # Q15382)

Catalog # RHEB-B-301

For Bulk Orders or Custom Packaging:  please contact

Loading of Rheb with nucleotides or nucleotides' analogs can be performed as a custom service.

Storage buffer: 20 mM HEPES, pH 7.5, 250 mM NaCl, 5 mM 2-mercaptoethanol, 1 mM MgCl2 and 10% Glycerol
Purity: >90% by Coomassie staining 
Storage is recommended at -20°C or lower for longer periods of time. 
Minimize freeze/thaw cycles. 

International Shipping:  Product requires shipping on ice packs. Please contact for shipment estimates

This product is for laboratory research use only.

Yu et al. Structural basis for the unique biological function of small GTPase RHEB. J Biol Chem2005 Apr 29; 280(17): 17093-100. doi: 10.1074/jbc.M501253200.

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