Rheb Protein, Human, Recombinant, Biotinylated

Rheb (Ras homolog enriched in brain) is a small GTPase that functions as an important mediator between the tumor suppressor proteins TSC1. Rheb shares about 30–40% sequence identity with members of the Ras/Rap subfamily of small GTPases. Human Rheb consists of 184 amino acid residues. The 169 N-terminal residues form the GTPase domain; the 15 C-terminal residues are hypervariable with a flexible structure and comprise a conserved carboxyl CAAX motif that plays important roles in the farnesylation of Rheb and its association with membrane (1).

Recombinant Rheb protein with the N-terminal AviTag™ peptide and His-tag is produced in E. coli cells and site-specifically biotinylated at AviTag with BirA enzyme.

Catalog # RHEB-B-301

This product is for laboratory research use only.