Neurofibromin (NF1), Human, Recombinant

Neurofibromin, the protein encoded by the NF1 tumor-suppressor gene, is a GTPase activating protein (GAP) of Ras (Ras-GAP). It downregulates the Ras signaling pathway by promoting the hydrolysis of the active form of Ras (GTP-bound Ras) to an inactive form of Ras (GDP-bound Ras) by increasing the intrinsic GTPase activity of Ras (1).

A GTPase Activating Domain from the human neurofibromatosis type 1 gene, NF1 (amino acids 1197-1530) with a polyhistidine tag at the N-terminus was expressed in E. coli.

Catalog # NF1-301

This product is for laboratory research use only.