Nucleotide-Loaded KRAS Proteins

Shop recombinant wild type, G12C, G12D, and G12V KRAS proteins supplied in defined GDP-loaded or GppNHp-loaded nucleotide states for exchange assays, effector binding studies, inhibitor profiling, and oncology research.

GDP-Loaded and GppNHp-Loaded KRAS

KRAS Proteins Supplied in Defined Nucleotide States

Shop recombinant KRAS proteins supplied pre-loaded with GDP or GppNHp for nucleotide-state-controlled assay workflows, including nucleotide exchange assays, effector binding studies, inhibitor profiling, SPR, BLI, AlphaScreen, MST, and oncology drug discovery.

GDP-Loaded KRAS

Useful for nucleotide exchange assays, SOS1-mediated exchange workflows, and experiments that begin from a defined inactive-state conformation.

GppNHp-Loaded KRAS

Useful for active-state KRAS assays, effector binding studies, inhibitor profiling, and workflows requiring a stable GTP-like state.

Custom Nucleotide Loading

Request GDP, GppNHp, GMPPNP, GTPγS, or other custom nucleotide-loaded RAS protein formats.

Choosing GDP-Loaded vs GppNHp-Loaded KRAS

Defined nucleotide-loaded KRAS proteins help reduce preparation steps and improve consistency in nucleotide-state-dependent biochemical workflows.

GDP-Loaded KRAS

  • Defined GDP-bound starting state
  • Useful for SOS1-mediated nucleotide exchange assays
  • Supports GDP-state binder and exchange workflow development
  • Useful when researchers want to initiate exchange under controlled conditions

GppNHp-Loaded KRAS

  • Stable non-hydrolyzable GTP-analog state
  • Useful for active-state KRAS assay workflows
  • Supports effector binding and inhibitor profiling
  • Helpful for workflows requiring a GTP-like conformation
Read the GDP vs GppNHp KRAS Guide Request Custom Nucleotide Loading

Need a Custom RAS Protein Format?

Request custom mutations, tag placement, site-specific biotinylation, GDP or GppNHp nucleotide loading, assay-ready formulations, custom QC, or bulk quantities.

Request Custom Protein Production

FAQ

When should I choose GDP-loaded KRAS?

Choose GDP-loaded KRAS when you want to begin from a defined inactive-state conformation, perform nucleotide exchange assays, or study SOS1-mediated exchange workflows.

When should I choose GppNHp-loaded KRAS?

Choose GppNHp-loaded KRAS when your assay requires a stable GTP-like active-state conformation, such as effector binding, inhibitor profiling, or active-state KRAS screening.

Are these products for research use only?

Yes. These products are for research use only and are not intended for diagnostic or therapeutic use.

Research Use Only. These products are for research use only and are not intended for diagnostic or therapeutic use.

Domestic Shipping in the US

Temperature sensitive products requiring shipping/handling on dry ice are shipped via UPS Next Day Air Saver. These products are delivered the next day if your order is placed before 3 PM PST. A dry ice surcharge is included in the shipping cost at checkout. For orders totaling over $1,000, free shipping and handling will be applied to the order.