RalA Protein, Human, Recombinant, Biotinylated
RalA Protein, Human, Recombinant, Biotinylated
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Ras-related protein Ral-A (RALA) is a member of the Ras GTPase family and shares a high structural similarity with RAS proteins (1). In human cells, the two protein isoforms, RALA and RALB, have been shown to play roles in the proliferation, survival, and metastasis of a variety of human cancers. RALA and RALB share 81% sequence homology with one another and more than 50% sequence homology with RAS. Given their importance in cancer biology, RAL proteins have emerged as desirable clinical targets (2).
Recombinant RalA protein with the N-terminal AviTag™ peptide and His-tag is produced in E. coli cells and site-specifically biotinylated at AviTag with BirA enzyme.
Catalog # RALA-B-301
This product is for laboratory research use only.
Tag(s): The N-terminal 8XHis and AviTag
Amino acids: 1-206 of RalA (UniProt # P11233)
Storage buffer: 20 mM Tris-HCl, pH 7.5, 100 mM NaCl, 2 mM DTT, 10% Glycerol
Molecular weight: ~27 kDa
Purity: >90% by Coomassie staining
Storage is recommended at -80°C
International Shipping: Product requires shipping on dry ice. Please contact info@amidbiosciences.com for shipment estimates.
For Bulk Orders or Custom Packaging: Contact info@amidbiosciences.com
References:
- Yan, C., Theodorescu, D. RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer. Pharmacol Rev. 2018, 70: 1–11; https://doi.org/10.1124/pr.117.014415
- Richardson, D. et al. The RAL Enigma: Distinct Roles of RALA and RALB in Cancer. Cells 2022, 11(10), 1645; https://doi.org/10.3390/cells11101645
Domestic Shipping in the US
Temperature sensitive products requiring shipping/handling on dry ice are shipped via UPS Next Day Air Saver. These products are delivered the next day if your order is placed before 3 PM PST. A dry ice surcharge is included in the shipping cost at checkout. For orders totaling over $1,000, free shipping and handling will be applied to the order.
International Shipping
Orders to be shipped internationally (outside of the US) can be shipped via DHL Express Worldwide or FedEx International Priority. Please contact info@amidbiosciences.com if you would like your company's shipping account to be used for the order. Our customers have sometimes negotiated lower shipping rates than us.
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