KRAS Effector & Regulatory Proteins

Shop KRAS pathway effector and regulatory proteins, including SOS1, RAF1-RBD, PI3Kα-RBD, RALGDS-RBD, NF1-GRD, SHP2, and related assay reagents.

KRAS Effector & Regulatory Proteins

Selecting KRAS Pathway Proteins for Your Assay

KRAS pathway assays often require more than KRAS alone. Use effector-domain proteins for KRAS binding studies, exchange factors such as SOS1 for nucleotide exchange workflows, regulatory proteins such as NF1-GRD for GAP-related assay development, and downstream pathway proteins for signaling and screening applications.

Effector Binding Proteins

Use RAF1-RBD, PI3Kα-RBD, RALGDS-RBD, and related effector-domain proteins to study KRAS interactions and downstream binding interfaces.

Exchange And Regulatory Proteins

Use SOS1, NF1-GRD, SHP2, and related regulatory proteins to support nucleotide exchange, pathway regulation, and assay-development workflows.

Custom Pathway Reagents

Request custom KRAS pathway domains, tag placement, linker(s), nucleotide-state workflows, labeled proteins, complexes, formulations, or bulk production.

Build a KRAS Pathway Assay Workflow

Pair KRAS effector and regulatory proteins with KRAS mutants, defined nucleotide-loaded KRAS formats, biotinylated capture reagents, or custom recombinant protein services.

Nucleotide-Loaded KRAS Proteins Biotinylated KRAS Proteins KRAS Effector & Regulatory Proteins Custom RAS Protein Services

Need a Custom RAS Protein Format?

Request custom mutations, tag placement, site-specific biotinylation, GDP or GppNHp nucleotide loading, assay-ready formulations, custom QC, or bulk quantities.

Request Custom Protein Production

FAQ

Which proteins are used for KRAS effector binding assays?

Common KRAS effector-binding reagents include RAF1-RBD, PI3Kα-RBD, RALGDS-RBD, and related effector-domain proteins used to study KRAS interactions and downstream signaling interfaces.

Which proteins support KRAS nucleotide exchange or regulatory assays?

SOS1 is commonly used for KRAS nucleotide exchange workflows, while NF1-GRD, SHP2, and related regulatory proteins support pathway regulation and assay-development studies.

Are these products for research use only?

Yes. These products are for research use only and are not intended for diagnostic or therapeutic use.

Research Use Only. These products are for research use only and are not intended for diagnostic or therapeutic use.

Domestic Shipping in the US

Temperature sensitive products requiring shipping/handling on dry ice are shipped via UPS Next Day Air Saver. These products are delivered the next day if your order is placed before 3 PM PST. A dry ice surcharge is included in the shipping cost at checkout. For orders totaling over $1,000, free shipping and handling will be applied to the order.