Amid Biosciences | Protein Engineering Company
RalB Protein, Human, Recombinant, Biotinylated
Ras-related protein Ral-B (RALB) is a member of the Ras GTPase family and shares a high structural similarity with RAS proteins (1). In human cells, the two protein isoforms, RALA and RALB, have been shown to play roles in the proliferation, survival, and metastasis of a variety of human cancers. RALA and RALB share 81% sequence homology with one another and more than 50% sequence homology with RAS. Given their importance in cancer biology, RAL proteins have emerged as desirable clinical targets (2).
Recombinant RalB protein with the N-terminal AviTag™ peptide and His-tag is produced in E. coli cells and site-specifically biotinylated at AviTag with BirA enzyme (https://amidbiosciences.com/collections/proteins/products/bira-biotin-ligase).
Tag(s): The N-terminal 8XHis and AviTag
Amino Acids: 1-206 of RalB (UniProt # P112334)
Catalog # RALB-B-301
Storage buffer: 20 mM Tris-HCl, pH 7.5, 100 mM NaCl, 2 mM DTT, 10% Glycerol.
Molecular weight: ~27 kDa
Purity: >90% by Coomassie staining
Storage is recommended at -80°C.
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This product is for laboratory research use only.References
1. Yan, C., Theodorescu, D. RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer. Pharmacol Rev. 2018, 70:1–11; https://doi.org/10.1124/pr.117.014415
2. Richardson, D. et al. The RAL Enigma: Distinct Roles of RALA and RALB in Cancer. Cells 2022, 11(10), 1645; https://doi.org/10.3390/cells11101645