Selecting a KRAS G12C Protein for Your Assay
KRAS G12C assays often depend on nucleotide state, covalent inhibitor workflow, immobilization strategy, and downstream binding partner. Use GDP-loaded KRAS G12C for GDP-state inhibitor profiling or exchange workflows, GppNHp-loaded KRAS G12C for active-state studies, and biotinylated KRAS G12C for streptavidin-based capture assays.
Defined KRAS G12C Reagents
Select KRAS G12C proteins by nucleotide state, biotinylation format, tag placement, mutation background, and assay workflow requirements.
Covalent Inhibitor Workflows
Use KRAS G12C proteins for covalent inhibitor profiling, nucleotide-state assays, effector binding studies, and biochemical screening workflows.
Custom KRAS G12C
Request custom KRAS G12C mutations, nucleotide loading, tag placement, linker(s), formulation, or bulk production.
Build a KRAS G12C Assay Workflow
Pair KRAS G12C proteins with defined nucleotide-loading formats, streptavidin-compatible biotinylated reagents, pathway interaction partners, resistance-relevant mutants, or custom protein services.
Need a Custom RAS Protein Format?
Request custom mutations, tag placement, site-specific biotinylation, GDP or GppNHp nucleotide loading, assay-ready formulations, custom QC, or bulk quantities.
FAQ
Do you offer nucleotide-loaded KRAS G12C?
Yes. KRAS G12C can be supplied in GDP-loaded or GppNHp-loaded formats for nucleotide-state-controlled assay workflows.
Can I request KRAS G12C resistance-related mutants?
Yes. Custom KRAS G12C-related mutations and double mutants can be requested for assay development, resistance-mechanism studies, and drug discovery workflows.
Are these products for research use only?
Yes. These products are for research use only and are not intended for diagnostic or therapeutic use.
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