BL21(DE3)pBirA Competent Cells for In vivo biotinylation of recombinant proteins | Chemically competent
High-efficiency Chemically competent E. coli cells optimized for In vivo biotinylation, AviTag protein expression, Recombinant protein expression, T7 promoter expression with transformation efficiency >1 × 10^4 CFU/µg pBR322.
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What are BL21(DE3)pBirA Competent Cells?
BL21(DE3)pBirA competent cells are optimized E. coli host cells developed for high-efficiency In vivo biotinylation of recombinant proteins workflows including In vivo biotinylation, AviTag protein expression, Recombinant protein expression, T7 promoter expression. These cells support reliable plasmid uptake, stable propagation, and reproducible transformation performance for molecular biology and protein engineering applications.
Why Choose This Strain?
- Transformation efficiency: >1 × 10^4 CFU/µg pBR322
- Specialized expression strain
- Supports plasmids up to Standard bacterial expression plasmids
- Stability: pBirA plasmid maintained with streptomycin/spectinomycin selection
Key Features
- Strain: BL21(DE3)pBirA
- Format: 10 × 0.1 mL/tube (20 reactions)
- Cell type: Chemically competent
- Insert compatibility: Expression construct-dependent
- Optimized for In vivo biotinylation of recombinant proteins
Applications
- In vivo biotinylation
- AviTag protein expression
- Recombinant protein expression
- T7 promoter expression
Workflow Compatibility
- BirA co-expression workflows
- AviTag biotinylation
- IPTG-inducible expression
- Biotinylated recombinant protein production
Specifications
| Genotype | fhuA2 [lon] ompT gal (λ DE3) [dcm] ∆hsdS pBirA(StrR) [λDE3 = λ sBamHIo ∆EcoRI-B int::(lacI::PlacUV5::T7 gene1) i21 ∆nin5] |
|---|---|
| Antibiotic Resistance | Streptomycin/Spectinomycin, Depends on expression vector |
| Growth Conditions | LB with streptomycin/spectinomycin plus expression-vector antibiotic; SOC recovery for transformation |
| Plasmid Types | pET vectors, pTrc vectors, T7 promoter-driven vectors, E. coli promoter-driven vectors, AviTag fusion expression plasmids |
| Recombination Notes | Optimized for BirA co-expression and in vivo biotinylation rather than reduced-recombination cloning |
| Max Plasmid Size | Standard bacterial expression plasmids |
Detailed Specifications
| Stability Type | pBirA plasmid maintained with streptomycin/spectinomycin selection |
|---|---|
| Insert Size Compatibility | Expression construct-dependent |
| Format | 10 × 0.1 mL/tube (20 reactions) |
Handling & Protocol
| Transformation Method | Heat shock |
|---|---|
| Protocol Time | ~2 hours to plating, plus overnight incubation; induction protocol adds 4–6 hours after IPTG/biotin addition |
| Recovery Time | 1 hour at 37°C in SOC |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry ice |
| Shelf Life | ~6 - 12 months at -80°C (typical competent cell stability) |
Industry Comparison
Comparable to BL21(DE3)-BirA co-expression systems for In vivo biotinylation of recombinant proteins workflows.
Comparable to BL21(DE3)-BirA co-expression systems designed for producing biotinylated AviTag-fused recombinant proteins in E. coli.
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Quality Control
- Transformation efficiency validated with control plasmid
- Genotype verified
- Contamination-free
- CoA provided
Key Advantages
- Enables in vivo biotinylation of AviTag-fused proteins
- Contains IPTG-inducible BirA expression plasmid
- Compatible with many E. coli and T7 promoter-driven vectors
- pBirA plasmid carries streptomycin/spectinomycin resistance
- Supports co-expression and protein production workflows
Why Researchers Choose Amid Biosciences Competent Cells
- High transformation efficiency for reliable cloning workflows
- Optimized strains for phage display, mutagenesis, and protein engineering
- Stringent quality control testing
- Fast shipping and scientific support
- Research-use-only products manufactured for reproducibility
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Research Use Only. Not for diagnostic or therapeutic use.