VAV1 Protein, Human, Recombinant, Biotinylated
VAV1 Protein, Human, Recombinant, Biotinylated
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The guanine nucleotide exchange factor (GEF) VAV1 plays an important role in T-cell activation and tumorigenesis. In the GEF superfamily, VAV1 has the ability to interact with multiple families of Rho GTPases. VAV1 regulates T/B cell receptor signaling, T cell activation, T helper cell differentiation, cytokine production, actin polymerization, and cytoskeleton reorganization via GEF-dependent and -independent pathways. Recent studies suggest that targeting VAV1 has therapeutic potential in T and T/B cell-mediated autoimmune and chronic inflammatory diseases (1, 2).
Recombinant human VAV1 protein with the N-terminal AviTag™ peptide and His-tag is produced in E. coli cells and site-specifically biotinylated at AviTag with BirA enzyme.
Catalog # VAV1-B-301
This product is for laboratory research use only.
Amino Acids: 178-574 of VAV1 (UniProt # P15498-1)
Tag(s): The N-terminal 6XHis and AviTag
Expression system: E.coli
Storage buffer: 20 mM Tris-HCl, pH 7.5, 100 mM NaCl, 5 mM 2-mercaptoethanol, 0.04 % Tween 20, 20% Glycerol
Concentration: 1.0 mg/mL by A280 (please see specific lot number)
Molecular weight: ~49.7 kDa
Purity: >85% by Coomassie staining
Storage is recommended at -80°C
For Bulk Orders or Custom Packaging: Contact info@amidbiosciences.com
International Shipping: Product requires shipping on dry ice. Please contact info@amidbiosciences.com for shipment estimates
References:
- Neurath, Markus F. et al. VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases. Trends in Immunology 2024, 45 (8), 580 – 596.
- Guerreiro-Cacais, A.O. et al. VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis. Genes Immun. 2017; 18:109.
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