VAV1 Protein, Human, Recombinant, Biotinylated

The guanine nucleotide exchange factor (GEF) VAV1 plays an important role in T-cell activation and tumorigenesis. In the GEF superfamily, VAV1 has the ability to interact with multiple families of Rho GTPases. VAV1 regulates T/B cell receptor signaling, T cell activation, T helper cell differentiation, cytokine production, actin polymerization, and cytoskeleton reorganization via GEF-dependent and -independent pathways. Recent studies suggest that targeting VAV1 has therapeutic potential in T and T/B cell-mediated autoimmune and chronic inflammatory diseases (1, 2).

Recombinant human VAV1 protein with the N-terminal AviTag™ peptide and His-tag is produced in E. coli cells and site-specifically biotinylated at AviTag with BirA enzyme.

Catalog # VAV1-B-301

This product is for laboratory research use only.