Recombinant Human STING Protein (H232 Variant) for Research Applications | Amid Biosciences

The Human STING (Stimulator of Interferon Genes) H232 variant (TMEM173) is a naturally occurring isoform characterized by a histidine substitution at amino acid 232. 

This high-purity, recombinant human STING protein represents the H232 variant which is heavily utilized in structural studies and assay development to understand STING's role in innate immune signaling pathways in a laboratory setting.
Unlike the R232, the H232 variant demonstrates reduced binding affinity to 2'-3' cGAMP

Key Features & Technical Specifications:

• Variant Specificity: Contains the H232 (His232) polymorphism, essential for studying natural variations in the STING signaling pathway.
• High Purity & Activity: Purified to >85% via affinity chromatography, ensuring consistent results in ligand-binding studies and enzymatic assays.
• Research Utility: Optimized for in-vitro analysis of 2'-3' cGAMP interactions and the characterization of downstream signaling cascades.
• Flexible Format: Available in multiple concentrations (including 0.1 mg and 1.0 mg) to support both small-scale screening and large-scale structural studies.
• Strictly for Research Use: This product is intended for laboratory research and development only. It is not for human or animal diagnostic or therapeutic use.