Saposin C, Human, Recombinant, His-tag

Human saposin C is small, heat-stable glycoprotein activator of lysosomal glycosphingolipid hydrolases that derive from a single precursor, prosaposin, by proteolytic cleavage. Of the prosaposin derived saposins, saposin C shows the highest amino acid identity/similarity to saposin A. Saposin C is an essential activator for glucocerebrosidase, the enzyme deficient in Gaucher disease (1, 2). It plays role in antigen presentation of lipids through CD1b to human T cells (3). Saposins are glycosylated in a native state; however, non-glycosylated recombinant saposins produced in E. coli retain their respective activation effects in functional in vitro assays (2).

Recombinant human saposin C with a C-terminal His-tag is produced in E. coli and purified by proprietary chromatography techniques.

Catalog # SAPC-301-1, SAPC-301-2

This product is for laboratory research use only.