BL21(DE3) pLPP Competent Cells for Production of unphosphorylated recombinant proteins | Chemically competent
High-efficiency Chemically competent E. coli cells optimized for Unphosphorylated protein expression, Lambda protein phosphatase co-expression, Recombinant protein expression, T7 promoter expression with transformation efficiency >1 × 10^4 CFU/µg pBR322.
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What are BL21(DE3) pLPP Competent Cells?
BL21(DE3) pLPP competent cells are optimized E. coli host cells developed for high-efficiency Production of unphosphorylated recombinant proteins workflows including Unphosphorylated protein expression, Lambda protein phosphatase co-expression, Recombinant protein expression, T7 promoter expression. These cells support reliable plasmid uptake, stable propagation, and reproducible transformation performance for molecular biology and protein engineering applications.
Why Choose This Strain?
- Transformation efficiency: >1 × 10^4 CFU/µg pBR322
- Specialized expression strain
- Supports plasmids up to Standard bacterial expression plasmids
- Stability: pLPP plasmid maintained with streptomycin/spectinomycin selection
Key Features
- Strain: BL21(DE3) pLPP
- Format: 10 × 0.1 mL/tube
- Cell type: Chemically competent
- Insert compatibility: Expression construct-dependent
- Optimized for Production of unphosphorylated recombinant proteins
Applications
- Unphosphorylated protein expression
- Lambda protein phosphatase co-expression
- Recombinant protein expression
- T7 promoter expression
Workflow Compatibility
- Lambda protein phosphatase co-expression
- Removal of Ser/Thr/Tyr phosphorylation
- Expression of homogeneously unphosphorylated proteins
- IPTG-inducible co-expression workflows
Specifications
| Genotype | fhuA2 [lon] ompT gal (λ DE3) [dcm] ∆hsdS pLPP (StrR) [λDE3 = λ sBamHIo ∆EcoRI-B int::(lacI::PlacUV5::T7 gene1) i21 ∆nin5] |
|---|---|
| Antibiotic Resistance | Streptomycin/Spectinomycin, Depends on expression vector |
| Growth Conditions | LB with streptomycin/spectinomycin plus expression-vector antibiotic; SOC recovery for transformation |
| Plasmid Types | pET vectors, pTrc vectors, T7 promoter-driven vectors, E. coli promoter-driven vectors |
| Recombination Notes | Optimized for lambda phosphatase co-expression rather than reduced-recombination cloning |
| Max Plasmid Size | Standard bacterial expression plasmids |
Detailed Specifications
| Stability Type | pLPP plasmid maintained with streptomycin/spectinomycin selection |
|---|---|
| Insert Size Compatibility | Expression construct-dependent |
| Format | 10 × 0.1 mL/tube |
Handling & Protocol
| Transformation Method | Heat shock |
|---|---|
| Protocol Time | ~2 hours to plating, plus overnight incubation; induction protocol adds 4–6 hours after IPTG addition |
| Recovery Time | 1 hour at 37°C in SOC |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry ice |
| Shelf Life | ~6 - 12 months at -80°C (typical competent cell stability) |
Industry Comparison
Comparable to BL21(DE3) lambda phosphatase co-expression systems for Production of unphosphorylated recombinant proteins workflows.
Comparable to BL21(DE3)-based lambda phosphatase co-expression systems used to produce unphosphorylated recombinant proteins in E. coli.
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Quality Control
- Transformation efficiency validated with control plasmid
- Genotype verified
- Contamination-free
- CoA provided
Key Advantages
- Contains IPTG-inducible lambda protein phosphatase expression plasmid
- Designed for production of homogeneously unphosphorylated proteins
- Lambda PP removes phosphorylation from Ser, Thr, and Tyr residues
- Compatible with many E. coli and T7 promoter-driven vectors
- pLPP plasmid carries streptomycin/spectinomycin resistance
Why Researchers Choose Amid Biosciences Competent Cells
- High transformation efficiency for reliable cloning workflows
- Optimized strains for phage display, mutagenesis, and protein engineering
- Stringent quality control testing
- Fast shipping and scientific support
- Research-use-only products manufactured for reproducibility
Related Products
- SS320 Competent Cells for Large Phage Display Libraries
- TG1 Competent Cells for Antibody Phage Display
- DH5α Competent Cells for Routine Cloning
Research Use Only. Not for diagnostic or therapeutic use.