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KRAS G12C Protein, Human, Recombinant, AviTag

Amid Biosciences | Protein Engineering Company

KRAS G12C Protein, Human, Recombinant, AviTag

$ 500.00

Human KRAS protein is a small guanosine triphosphatase (GTPase) that is the component of the mitogen activated protein kinase (MAPK) signaling pathway. High occurrences of KRAS mutations in some types of cancers make KRAS one of the most important targets in oncology for drug development.  The four most frequent KRAS mutations are G12D, G12V, G13D, and G12C.

KRAS G12C, Human, Recombinant, AviTag | Amid Biosciences

Image from National Cancer Institute (NCI):  https://visualsonline.cancer.gov/details.cfm?imageid=11166

Recombinant KRAS G12C protein with the N-terminal AviTag™ peptide and His-tag is produced in E. coli cells. Presence of AviTag™ peptide can be useful for a site-specific biotinylation with BirA enzyme (https://amidbiosciences.com/collections/proteins/products/bira-biotin-ligase).

Sequence of recombinant human KRAS G12C protein (amino acids 1 – 185; G12C mutant variant of isoform 2B (UNIPROT: P01116-2))

MGSHHHHHHHHSNGLNDIFEAQKIEWHEMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCL

LDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQD

LARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKC


Catalog # KRAS12C-301

For Bulk Orders or Custom Packaging:  please contact info@amidbiosciences.com

Storage buffer: 10 mM Tris-HCl, pH 7.5, 100 mM NaCl, 1 mM DTT and 50% Glycerol. 
Concentration: 1.0 mg/mL by A280 
Purity: >90% by Coomassie staining 
Storage is recommended at -20°C for longer periods of time. 

International Shipping:  Product requires shipping on ice packs. Please contact info@amidbiosciences.com for shipment estimates

This product is for laboratory research use only.


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