{"product_id":"saposin-c-human-recombinant-his-tag","title":"Saposin C, Human, Recombinant, His-tag","description":"\u003cp\u003e\u003cstrong\u003eSaposin C\u003c\/strong\u003e (SAP-C) is a small, heat-stable lysosomal glycoprotein derived from the prosaposin precursor protein via site-specific proteolytic cleavage. Among the four prosaposin-derived domains, Saposin C shares the highest structural and sequence homology with Saposin A. It acts as an indispensable biological cofactor required for the lysosomal activation of β-glucocerebrosidase (GBA), the enzyme deficient in Gaucher disease. Additionally, Saposin C plays a critical role in cellular immunology by facilitating the presentation of lipid antigens through CD1b molecules to human T cells. While native lysosomal saposins are heavily glycosylated, non-glycosylated recombinant variants expressed in bacterial systems maintain full biological activation properties in functional \u003cem\u003ein vitro\u003c\/em\u003e biochemical assays.\u003c\/p\u003e\n\u003ch3\u003eProduct Features \u0026amp; Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression System:\u003c\/strong\u003e Engineered and expressed in an optimized \u003cem\u003eEscherichia coli\u003c\/em\u003e (\u003cem\u003eE. coli\u003c\/em\u003e) bacterial host.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFusion Tag:\u003c\/strong\u003e Features a C-terminal Polyhistidine (6xHis) tag to allow robust detection, tracking, and oriented immobilization.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Purity:\u003c\/strong\u003e Verified at \u0026gt;90% purity by Coomassie blue staining on SDS-PAGE.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation \u0026amp; Concentration:\u003c\/strong\u003e Supplied at a concentration of 1.0 mg\/mL (determined by A280) in 10 mM Tris-HCl, pH 7.5, 100 mM NaCl, and 50% Glycerol for premium structural stability.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eValidated Assay Applications\u003c\/h3\u003e\n\u003cp\u003eThis recombinant human Saposin C construct is specifically optimized for lysosomal enzyme activity assays, \u003cem\u003ein vitro\u003c\/em\u003e glucocerebrosidase reconstitution kinetics, lipid-binding biophysical studies, CD1b lipid antigen presentation assays, Surface Plasmon Resonance (SPR), and Bio-Layer Interferometry (BLI).\u003c\/p\u003e\n\u003cp\u003e\u003csmall\u003e\u003cem\u003eCatalog Numbers: SAPC-301-1 (0.1 mg) | SAPC-301-2 (1.0 mg). \u003cstrong\u003eThis product is intended for laboratory research use only (RUO).\u003c\/strong\u003e It is not intended for diagnostic or therapeutic use in humans or animals.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e","brand":"Amid Biosciences","offers":[{"title":"0.1 mg","offer_id":12475963768913,"sku":"SAPC-301-1","price":600.0,"currency_code":"USD","in_stock":true},{"title":"1.0 mg","offer_id":59537121280081,"sku":"SAPC-301-2","price":2800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0981\/2236\/files\/Saposin_C_Human_Recombinant_His-tag.png?v=1779505009","url":"https:\/\/amidbiosciences.com\/products\/saposin-c-human-recombinant-his-tag","provider":"Amid Biosciences","version":"1.0","type":"link"}