{"product_id":"recombinant-human-saposin-b-protein","title":"Saposin B, Human, Recombinant","description":"\u003cp\u003e\u003cstrong\u003eSaposin B\u003c\/strong\u003e (SAP-B) is a small, non-enzymatic glycosphingolipid activator protein essential for the lysosomal degradation of cerebroside sulfates (sulfatides). It functions as a biological detergent, physically extracting target lipid molecules from biological membranes to form a soluble, transportable protein-lipid complex. This presentation renders the substrate accessible to the hydrolytic enzyme arylsulfatase A (ARSA). Deficiencies or genetic mutations in the prosaposin gene leading to a loss of functional Saposin B result in Saposin B deficiency, a rare lysosomal storage disease phenotypically resembling metachromatic leukodystrophy (MLD).\u003c\/p\u003e\n\u003ch3\u003eKey Research \u0026amp; Assay Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnzyme Replacement \u0026amp; Activity Assays:\u003c\/strong\u003e Ideal as a functional cofactor for reconstituting \u003cem\u003ein vitro\u003c\/em\u003e arylsulfatase A degradation kinetics and lipid editing mechanics.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunology \u0026amp; NKT Cell Activation:\u003c\/strong\u003e Used in downstream investigations profiling phospholipid transfer dynamics and lipid antigen presentation to Natural Killer T (NKT) cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Discovery Support:\u003c\/strong\u003e High-value target component for screening therapeutics, small molecules, or chaperone designs aiming to mitigate metachromatic leukodystrophy pathways.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eProduct Features \u0026amp; Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression System:\u003c\/strong\u003e Engineered and produced in an optimized \u003cem\u003eEscherichia coli\u003c\/em\u003e (\u003cem\u003eE. coli\u003c\/em\u003e) bacterial expression platform.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag Status:\u003c\/strong\u003e Expressed as an N-terminal His-tag fusion and purified using proprietary chromatography steps, followed by site-specific proteolytic cleavage to yield a completely \u003cstrong\u003etag-free\u003c\/strong\u003e final protein.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence Profile:\u003c\/strong\u003e Comprises the native 79-amino acid mature Saposin B sequence (GDVCQDCIQM...CDE).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Purity:\u003c\/strong\u003e Formulated to \u0026gt;90% purity as verified by Coomassie blue staining on SDS-PAGE.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBuffer Formulation:\u003c\/strong\u003e Supplied at a concentration of 0.5 – 2.0 mg\/mL in 25 mM Phosphate Buffer, pH 7.2, 75 mM NaCl, and 50% Glycerol for premium structural stability.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003e\u003cem\u003eCatalog Number: SAPB-301 | \u003cstrong\u003eThis product is intended for laboratory research use only (RUO)\u003c\/strong\u003e. Long-term storage is recommended at -20°C.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e","brand":"Amid Biosciences","offers":[{"title":"0.1 mg","offer_id":32396239110225,"sku":"SAPB-301-1","price":600.0,"currency_code":"USD","in_stock":true},{"title":"1.0 mg","offer_id":59537119248465,"sku":null,"price":2800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0981\/2236\/files\/Saposin_B_Human_Recombinant.png?v=1779504561","url":"https:\/\/amidbiosciences.com\/products\/recombinant-human-saposin-b-protein","provider":"Amid Biosciences","version":"1.0","type":"link"}