{"product_id":"recombinant-human-saposin-a-protein","title":"Saposin A, Human, Recombinant","description":"\u003cp\u003e\u003cstrong\u003eSaposin A\u003c\/strong\u003e is a small, highly stable, cysteine-rich alpha-helical glycoprotein localized within the lysosomal compartment. Derived from the prosaposin precursor protein, it serves as an essential non-enzymatic cofactor required for the lysosomal degradation of galactosylceramide by β-galactosylceramidase. While native saposins are glycosylated, non-glycosylated recombinant saposins retain their full biological activation properties in functional \u003cem\u003ein vitro\u003c\/em\u003e assays, making them exceptional tools for membrane biophysics.\u003c\/p\u003e\n\u003ch3\u003eKey Applications: Lipid Nanoparticle Scaffolding\u003c\/h3\u003e\n\u003cp\u003eBeyond its native role in sphingolipid catabolism, recombinant Saposin A is widely utilized as a scaffolding protein in versatile lipid nanoparticle systems (saposin-lipoprotein discs). These engineered scaffolds allow researchers to reconstitute challenging membrane proteins and transporters into a native-like lipid bilayer. This technology is highly valued across structural biology (including cryo-EM determination), targeted therapeutic delivery of protein-based pharmacological agents, and vaccine adjuvant formulation.\u003c\/p\u003e\n\u003ch3\u003eProduct Features \u0026amp; Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression Host:\u003c\/strong\u003e Produced in an optimized \u003cem\u003eEscherichia coli\u003c\/em\u003e (\u003cem\u003eE. coli\u003c\/em\u003e) bacterial expression system.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag Status:\u003c\/strong\u003e Expressed as an N-terminal His-tag fusion and purified using proprietary chromatography steps, followed by site-specific proteolytic cleavage to yield a completely \u003cstrong\u003etag-free\u003c\/strong\u003e final protein.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Purity:\u003c\/strong\u003e Verified at \u0026gt;90% purity by Coomassie blue staining on SDS-PAGE.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation \u0026amp; Concentration:\u003c\/strong\u003e Supplied at 1.0 – 2.0 mg\/mL in 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, and 50% Glycerol for premium stability.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003e\u003cem\u003eCatalog Number: SAPA-301 | \u003cstrong\u003eThis product is intended for laboratory research use only (RUO)\u003c\/strong\u003e. Shipping on ice packs required.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e","brand":"Amid Biosciences","offers":[{"title":"0.1 mg","offer_id":12475835154513,"sku":"SAPA-301-1","price":600.0,"currency_code":"USD","in_stock":true},{"title":"1.0 mg","offer_id":59537114955857,"sku":"SAPA-301-2","price":2800.0,"currency_code":"USD","in_stock":true},{"title":"10.0 mg","offer_id":59537117184081,"sku":"SAPA-301-10","price":7500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0981\/2236\/files\/Saposin_A_Human_Recombinant.png?v=1779503974","url":"https:\/\/amidbiosciences.com\/products\/recombinant-human-saposin-a-protein","provider":"Amid Biosciences","version":"1.0","type":"link"}