{"product_id":"biotinylated-human-tl1a-protein-recombinant","title":"TL1A Protein, Human, Recombinant, Biotinylated","description":"\u003cp\u003e\u003cstrong\u003eTL1A\u003c\/strong\u003e, also known as \u003cstrong\u003eTNFSF15\u003c\/strong\u003e, is a tumor necrosis factor (TNF) family member cytokine predominantly expressed by monocytes, macrophages, dendritic cells (DCs), synovial fibroblasts, and endothelial cells. Its cognate cell surface receptor, DR3 (TNFRSF25), is primarily expressed on T cells, where TL1A signaling co-stimulates T-cell activation and drives pro-inflammatory cytokine production. Dysregulation of the TL1A\/DR3 pathway is strongly linked to human inflammatory bowel disease (IBD), Crohn's disease, and various autoimmune pathologies, making it a high-value target for therapeutic antibody screening and biomarker validation.\u003c\/p\u003e\n\n\u003ch3\u003eProduct Features \u0026amp; Specifications\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eExpression System:\u003c\/strong\u003e Engineered and expressed in an optimized \u003cem\u003eE. coli\u003c\/em\u003e bacterial system.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eConstruct Design:\u003c\/strong\u003e Features a DNA sequence encoding human TL1A (Gln58-Leu251) fused with an N-terminal Polyhistidine (His) tag and an AviTag™ peptide sequence.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003ePrecision Biotinylation:\u003c\/strong\u003e Enzymatically biotinylated at the unique AviTag™ site, ensuring uniform molecular orientation and maximum ligand binding capacity.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eNative Conformation:\u003c\/strong\u003e Size-exclusion chromatography (SEC) data confirms that the purified recombinant protein elutes as a fully functional homogenous trimer.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eHigh Purity:\u003c\/strong\u003e Verified at \u0026gt;90% purity by Coomassie blue staining on SDS-PAGE under reducing conditions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eValidated Assay Applications\u003c\/h3\u003e\n\u003cp\u003eThis biotinylated human TL1A protein is specifically optimized for high-sensitivity binding assays, surface plasmon resonance (SPR), bio-layer interferometry (BLI), AlphaLISA, and ELISA-based high-throughput screening of neutralizing anti-TL1A antibodies.\u003c\/p\u003e\n\n\u003cp\u003e\u003csmall\u003e\u003cem\u003eCatalog Number: TL1A-B-301 | This product is intended for research use only.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e ","brand":"Amid Biosciences","offers":[{"title":"0.1 mg","offer_id":39301355012177,"sku":"TL1A-B-301-1","price":600.0,"currency_code":"USD","in_stock":true},{"title":"1.0 mg","offer_id":59537201889361,"sku":"TL1A-B-301-2","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0981\/2236\/products\/TL1A_Protein_Human_Recombinant_Biotinylated.jpg?v=1779483049","url":"https:\/\/amidbiosciences.com\/products\/biotinylated-human-tl1a-protein-recombinant","provider":"Amid Biosciences","version":"1.0","type":"link"}