{"product_id":"biotinylated-human-tl1a-protein-recombinant-c-terminal","title":"TL1A Protein, Human, Recombinant, Precision C-Terminal Biotinylated","description":"\u003cp\u003e\u003cstrong\u003eTL1A\u003c\/strong\u003e, also known as \u003cstrong\u003eTNFSF15\u003c\/strong\u003e, is a tumor necrosis factor (TNF) family member cytokine predominantly expressed by monocytes, macrophages, dendritic cells (DCs), synovial fibroblasts, and endothelial cells. Its cognate cell surface receptor, DR3 (TNFRSF25), is primarily expressed on T cells, where TL1A signaling co-stimulates T-cell activation and drives pro-inflammatory cytokine production. Dysregulation of the TL1A\/DR3 pathway is strongly linked to human inflammatory bowel disease (IBD), Crohn's disease, and various autoimmune pathologies, making it a high-value target for therapeutic antibody screening and biomarker validation.\u003c\/p\u003e\n\u003ch3\u003eProduct Features \u0026amp; Specifications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression System:\u003c\/strong\u003e Engineered and expressed in an optimized \u003cem\u003eE. coli\u003c\/em\u003e bacterial system.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConstruct Design:\u003c\/strong\u003e Features a DNA sequence encoding human TL1A (Ser57-Leu251) fused with a C-terminal AviTag™ peptide sequence and a C-terminal His-tag.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrecision Biotinylation:\u003c\/strong\u003e Site-specifically biotinylated at the C-terminal AviTag™ using BirA enzyme, ensuring uniform molecular orientation and maximum ligand binding capacity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Mass:\u003c\/strong\u003e Resolves at approximately ~25 kDa (monomer) under reducing conditions on SDS-PAGE.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Purity:\u003c\/strong\u003e Verified at \u0026gt;90% purity by Coomassie blue staining.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage Buffer:\u003c\/strong\u003e Supplied in 20 mM Phosphate buffer, pH 7.4, 120 mM NaCl, 5 mM 2-mercaptoethanol, and 10% glycerol for optimal long-term stability.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eValidated Assay Applications\u003c\/h3\u003e\n\u003cp\u003eThis precision C-terminal biotinylated human TL1A protein is specifically optimized for high-sensitivity binding assays, surface plasmon resonance (SPR), bio-layer interferometry (BLI), AlphaLISA, and streptavidin-coated plate ELISA high-throughput screening of neutralizing anti-TL1A antibodies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003csmall\u003e\u003cem\u003eCatalog Number: TL1A-B-C-301 | This product is intended for laboratory research use only (ROU).\u003c\/em\u003e\u003c\/small\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Amid Biosciences","offers":[{"title":"0.1 mg","offer_id":59153241538641,"sku":"TL1A-B-C-301","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0981\/2236\/files\/TL1A_Protein_Human_Biotinyated_at_the_C-terminus.png?v=1779476910","url":"https:\/\/amidbiosciences.com\/products\/biotinylated-human-tl1a-protein-recombinant-c-terminal","provider":"Amid Biosciences","version":"1.0","type":"link"}